Proteopathic Seeds and Neurodegenerative Diseases (Research and Perspectives in Alzheimer's Disease)

Thông tin sách: Proteopathic Seeds and Neurodegenerative Diseases (Research and Perspectives in Alzheimer's Disease) (Hardcover, 168 trang) – Springer, 2013. Ngôn ngữ: Tiếng Anh.

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer´s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​ Editorial Reviews Review

"This is a current comprehensive text of the biochemical mechanisms of gene and protein expression encountered in Alzheimer's, Parkinson's, ALS, MS, prion disorders, and other degenerative diseases. ... Neurologists, neurophysiologists, biochemists, graduate students, postdocs, and anyone in drug development will find it very useful in their work." (Joseph J. Grenier, Amazon.com, January, 2016)

This is a current comprehensive text of the biochemical mechanisms of gene and protein expression encountered in Alzheimer s, Parkinson s, ALS, MS, prion disorders, and other degenerative diseases. Neurologists, neurophysiologists, biochemists, graduate students, postdocs, and anyone in drug development will find it very useful in their work. (Joseph J. Grenier, Amazon.com, January, 2016)

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This is a current comprehensive text of the biochemical mechanisms of gene and protein expression encountered in Alzheimer s, Parkinson s, ALS, MS, prion disorders, and other degenerative diseases. Neurologists, neurophysiologists, biochemists, graduate students, postdocs, and anyone in drug development will find it very useful in their work. (Joseph J. Grenier, Amazon.com, January, 2016)"

From the Back Cover

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans, and appears to occur many years before the onset of clinical symptoms. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, has increasingly implicated corruptive protein templating, or seeding, as a prime factor in the neurodegenerative process. The prion-like corruption of proteins also characterizes such clinically and etiologically diverse neurological disorders as Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of affected proteins thus could reveal universal principles and common therapeutic targets forsome of the most devastating and intractable human brain disorders.